There is ever-growing demand for faster, safer and more economical chemical reactions, leading to the adoption of novel synthesis protocols, such as continuous flow techniques. Optimizing these methods requires a thorough understanding of a reaction’s mechanism and kinetics to maximize yields and minimize impurities.
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HPLC is a valuable tool to help you understand and optimize important reaction variables, but is not always sufficient to identify what is happening between samples. Combining HPLC with in situ analyses offers a more comprehensive picture of your reactions, providing valuable insights to accelerate the development of new methods.
Using a number of recently published examples, this white paper shows how to combine HPLC with in situ analytical techniques to improve synthesis. It covers:
- Hidden reaction mechanisms – Detecting transient intermediates in a coupling reaction
- Reaction insights at -78 °C – Optimization of a lithiation reaction
- Endpoint prediction before sampling – Using hydrogenation monitoring to identify reaction completion
- Rapid reaction status checks – Identifying decomposition leading to epimerization while waiting for HPLC results
- Data-dense kinetics – Determining multiple kinetic reaction parameters from a single experiment