Crystallization

Efficient crystallization relies on finding the optimal balance between a number of different processes. Relying on trial-and-error approaches, without an understanding of these mechanisms and how they are inter-related, makes it difficult to optimize yield, purity and crystal size. In this guide you will find the key mechanistic considerations when developing a crystallization scheme.

Designing an effective crystallization process relies on understanding the various mechanisms at play, and how they interact. This knowledge can be used to develop efficient crystallization protocols that yield a product with the desired properties, without having to resort to laborious trial-and-error experimentation.

This useful guide outlines the key mechanistic considerations when developing a crystallization scheme, including:

  • Nucleation
  • Growth
  • Oiling out
  • Agglomeration
  • Breakage
  • Seeding
  • Polymorph transformation